How does targeted muscle reinnervation work




















You may also send these records to our office ahead of time. Depending on the type of surgery you need, your TMR procedure may be scheduled between about two weeks and three months after your first consultation.

TMR surgery typically takes between two and four hours and often requires a one- to five-day hospital stay, depending on the extent of your operation and the postsurgery pain management you need. Those who have a new amputation and receive primary TMR should expect postsurgery follow-up appointments scheduled at the two-week, four-week, three-month, six-month and month marks, with annual follow-ups.

If needed, discussions about your prosthetic typically begin between two and four weeks after amputation surgery. About four to six weeks after surgery, the prosthetic-fitting process may begin, along with stump-molding and fabrication of a trial prosthesis. Commonly you will receive a prosthesis between six and eight weeks after surgery.

Recovery time from amputation and primary TMR varies from person to person, as some amputations present dramatic life changes. Amputees who typically use a prosthetic should expect to abstain from using it for six weeks while healing after surgery.

Follow-up appointments commonly are scheduled at the two-week, four-week, three-month, six-month and month marks after surgery, with annual follow-ups. Secondary TMR patients typically can expect to be able to work again as soon as two weeks after surgery, depending on the type of work. Follow-up appointments will be scheduled based on your individual needs. Depending on their work, patients with these procedures typically can expect to be able to work again as soon as two weeks after surgery.

The Ohio State University Wexner Medical Center is home to TMR experts who are leading the way both in performing the procedure and in developing research surrounding its use. The Ohio State Wexner Medical Center TMR team includes plastic and reconstructive surgeons, orthopedic surgeons, physical therapists, physician assistants and nurses who specialize in the procedure and are part of a uniquely multidisciplinary network of care providers developing individualized treatment plans for patients.

By clicking "Subscribe" you agree to our Terms of Use. We'll be in touch every so often with health tips, patient stories, important resources and other information you need to keep you and your family healthy. When myo-testing indicates three or more potential independent isolated myoelectric sites, prosthesis control training can begin.

Amputation results in not only the loss of the limb, but also loss of the receptors and pathways of the somatosensory system, which transmits sensory and positional information back to the brain. Amputees must therefore rely exclusively on visual feedback to monitor their prostheses.

This creates an overwhelming cognitive load for individuals with amputations: they must constantly watch their prosthesis to monitor where it is and what it is doing.

Tactile feedback is important for successful manipulation of objects and plays a role in learning of new tasks and refining active movement. TMR surgery was developed to allow access to motor control information intended for the missing limb, but an unexpected discovery after the first TMR procedure indicates that TMR may also provide a pathway to allow sensory feedback from a prosthesis.

Sensory nerve fibers from transferred nerves can grow through the muscle and into the overlying skin, reestablishing functional connections with sensory end organs. Transfer sensation differs from phantom limb sensation, which likely results from changes in functional connectivity and reorganization within the central nervous system and thus is difficult to localize. Transfer sensation arises from the reactivation of amputated and transferred sensory afferents, and is thus felt as being precisely located to discrete areas on the missing limb.

A recent case study in which sensory nerve fascicles were directly transferred to surgically bisected cutaneous sensory nerves during conventional TMR surgery demonstrated discrete, separate sensory percepts of individual digits, which enabled precise sensory feedback while controlling a myoelectric arm. All data were obtained under approved protocols from the Institutional Review Boards of the appropriate institutions. Subjects ages ranged from , and average duration between amputation and TMR surgery was 16 months, with a range of 4 months to 6 years.

Neither age nor time since amputation had any noticeable effect on outcomes. All of these subjects had TMR performed on one side, although several patients had bilateral amputations. Since publication of Targeted Muscle Reinnervation: A Neural Interface for Artificial Limbs , bilateral TMR has been performed on a patient with a right-side transhumeral amputation and a left-side shoulder disarticulation amputation.

Mean operative time for transhumeral surgeries was 3 hours, 22 minutes; for shoulder disarticulation surgeries, the mean duration was 5 hours, 37 minutes. Surgical time was most likely longer for shoulder disarticulation surgeries because of the challenges imposed by altered anatomy due to high-impact injuries. However, not all signals were suitable for prosthesis control due to cross talk or difficulty in maintaining adequate electrode contact with skin.

Box and Block test — Subjects move one-inch blocks from one side of a box, over a partition, to the other side of the box. A higher score indicates improvement. Clothespin Relocation test — Subjects are timed as they move three clothespins from a horizontal bar, rotate them, and place them on a vertical bar.

Adapted from the Rolyan Graded Pinch Exerciser, this test requires control of all three available degrees of freedom of the prosthesis, including wrist rotation. A lower score indicates improvement. This test evaluates motor skills, in particular how effectively and efficiently the subjects moves when grasping and manipulating objects during the task.

The process skills evaluates the subject for task organization, planning, problem solving. Similar to the Box and Block test, a higher score indicates improvement.

After TMR, most subjects showed increased scores in both motor and process skills, and four out of five subjects demonstrated significant improvements in motor scores. The DASH consists of 30 scored questions on physical function, symptoms, and social functioning; the higher the score, the higher the level of disability experienced. Conventional EMG control techniques are based on the magnitude of EMG signals and give users basic control of powered prostheses.

However, these techniques are relatively primitive; they use only a fraction of the available control information and are confounded by muscle cross talk—EMG signals from other adjacent muscles. Consequently, these techniques require specific electrode placement, achieved through trial and error, to optimize control. This can be challenging in individuals with high level amputations, as they need to control several degrees of freedom but have few suitable control sites available.

In addition, because few residual muscles remain after above-elbow amputation, the user must often control several degrees of freedom using one muscle pair. This means that the user must use unintuitive contractions to control the prosthesis, for example, using the biceps and triceps to control the hand and wrist.

The user must also switch the prosthesis, for example, from hand to elbow mode. Mode-switching is often done by co-contraction. Pattern recognition provides an exciting new way to control a myoelectric prosthesis. Different attempted movements generate distinct, characteristic patterns of muscle activation, which in turn, generates unique EMG patterns—like an electrical fingerprint. Computer algorithms can learn to recognize and distinguish these patterns; once trained, the algorithm can then decipher what the user intends to do and command the prosthesis to perform that movement.

Pattern recognition makes control of a prosthesis more intuitive, or natural: the user simply has to try to make the desired movement with their residual limb, and the prosthesis responds with the correct movement. In addition, users do not have to switch the prosthesis between modes to control different degrees of freedom, so control is seamless. Pattern recognition technology also does not require specific electrode placement, which makes clinical fitting simpler and faster.

Although pattern recognition works for people who have not had TMR, an individual who has undergone TMR may benefit even more from pattern recognition, because TMR creates additional EMG signals that can be incorporated into the patterns, creating a more detailed pattern. TMR also allows access to the rich neural information that is carried by transferred brachial plexus nerves for control of the arm, hand, and digits. After the neuroma is removed, TMR can be performed to decrease the chance of it coming back.

With their complicated surgeries behind them, Patangi Amin and Ana Costa reflect on their experiences, sharing what has made them stronger.

New Brunswick , NJ Procedure Enables Some Nerves to Regenerate Targeted muscle reinnervation TMR is a procedure performed in patients undergoing limb amputation or in patients with painful neuromas after nerve injury. Our Quality Testimonials Appointments. Four time-domain features 3 , 15 were extracted from EMG signals in each analysis window. The combined features from the even-numbered trials were used to create a linear discriminant analysis classifier.

The classification accuracy for each movement was the percentage of total analysis windows for that class that were correctly classified. The overall classification accuracy was the average of these values for all 11 movements. The linear discriminant analysis classifier was then used in real time to classify features extracted from real-time EMG signals, produce a new prediction of the motion class every ms, and control a virtual-reality arm or a physical prosthesis, as described below.

Computational time for each analysis window was less than 3 ms. Experiments with a virtual prosthesis were performed immediately after classifier training. All participants were instructed to follow visual prompts for each movement, and a virtual arm that responded to the classifier output was displayed on the screen Figure 2.

Once the participants correctly selected the desired movement, they were asked to maintain it until the virtual arm completed the movement.

Each of the 10 motions was randomly presented 3 times in a trial, and the trials were repeated 6 times for a total of movements 72 hand-grasp motions and elbow and wrist motions. These data were used to evaluate the speed and consistency of control using real-time pattern recognition.

The motion selection time was the time taken to correctly select a target motion and was defined as the time from movement onset to the first correct classification Figure 3. This quantity measures how quickly motor commands can be translated into correct motion predictions. The motion completion time was defined as the time from movement onset to the 10th correct classification which represented the full range of motion for any movement Figure 3.

The fastest possible speed to complete any motion was 1 second, corresponding to 10 consecutive correct classifications, with new classifications occurring every ms. If the correct class was not selected within a 5-second time limit, the movement was considered a failure. The motion completion rate was the percentage of successfully completed motions out of the total attempted motions 72 attempted motions for the hand, attempted motions for the elbow and wrist within the time limit.

Because the motion selection and motion completion data for each participant were highly skewed, the median value for all 6 arm movements elbow and wrist and all 4 hand movements hand open and 3 hand grasps were calculated for each participant, and these values were averaged across the 5 patients who had undergone TMR and the 5 control participants.

Preliminary research demonstrated that hand-grasp patterns were more difficult to perform than elbow and wrist movements. Therefore, the control scheme for hand grasps was modified. A hand grasp could only be selected when the hand was fully open.

Once a grasp was selected, any hand-grasp pattern would close the hand in the initially selected grasp. However, if the initial hand-grasp pattern selected was incorrect, the patient would have to fully open the hand and try again. Three of the patients who had undergone TMR surgery were able to test advanced upper arm prosthesis prototypes developed under the Defense Advanced Research Project Agency's Revolutionizing Prosthetics program.

Video of this initial testing is presented in the Multimedia feature. The Johns Hopkins University Applied Physics Laboratory and collaborators developed a prosthetic arm with 7 degrees of freedom that was tested with patient S1 in January Patient S1 controlled flexion and extension of the motorized shoulder by using residual shoulder motion to operate a mechanical rocker switch.

A motorized humeral rotator was controlled with EMG signals from the residual deltoid and latissimus dorsi muscles. Humeral rotation was controlled with EMG signals from the latissimus dorsi and deltoid muscles.

The powered elbow, wrist, and hand were controlled with pattern recognition of EMG signals recorded over reinnervated muscles. For patient T5, the humeral rotator was controlled with a switch, while the elbow, wrist, and hand were controlled with pattern recognition of EMG signals recorded over reinnervated muscles.

The DEKA hand had multiple motors and was able to form a variety of hand-grasp patterns, including those shown in Figure 2. Surface electrodes were either self-adhesive or built into the patients' prosthetic sockets. The arm systems were trained at the beginning of each session with a short pattern-recognition protocol similar to the one described above.

Training and testing with the prostheses occurred over a 2-week period for each patient. Sessions generally lasted 2 to 3 hours, with one session in the morning and one in the afternoon. The majority of movements were selected quickly, with motion selection times less than 0.

The mean motion completion rate for elbow and wrist movements was high For TMR patients, the selection of the appropriate hand-grasp patterns took longer and had, on average, a 9. For control participants, the mean motion selection time for hand grasps was similar to that of elbow and wrist movements Table. The motion completion rate for hand grasps was slightly 3.

The movements performed by TMR patients as well as control participants were also completed quickly, consistent with the high classification rates Figure 4. The fastest possible motion completion time was 1 second, representing perfect classification of the intended movement. The mean motion completion times for elbow and wrist movements were 1.

For both groups, hand grasps took longer to complete than arm movements; the mean motion completion times for hand grasps were 1. The mean motion completion rates within a 3-second time limit were The motion completion rate for hand grasps was lower for 2 of the 5 TMR patients.

The motion completion rate increased as the time limit was increased up to approximately 2 seconds and then began to plateau; the maximum motion completion rate was generally reached by 6 seconds.

Building on the virtual-arm training experience, 3 patients who had undergone TMR surgery were able to demonstrate control of physical arm systems Multimedia feature. All 3 patients were able to perform basic operations using pattern-recognition control on the first day of testing. Over a 2-week trial period, their proficiency improved with practice, systems debugging, and minor systems improvements. The patients were able to operate all functions of the prosthetic arm prototypes.

Control of arm and hand movements using pattern-recognition of EMG signals from reinnervated muscles provided the ability for intuitive, sequential control of the elbow, wrist, and hand. The patients with shoulder-disarticulation amputation were able to simultaneously operate the shoulder and arm. Patients generally performed 1 motion at a time and would occasionally operate 2 joints simultaneously for reaching tasks.

The joints on these prostheses were capable of relatively high speeds. The speed range was customized to each patient, because the patients preferred to operate the arms at slower speeds to allow more accurate control. This control is demonstrated by patient S1 catching checkers rolling across a table, patient S2 stirring a spoon in a cup, and patient T5 moving small blocks Multimedia feature.

The powered-shoulder systems markedly increased the work space of the prostheses. Motorized shoulder flexion allowed the patients with shoulder-disarticulation amputation to reach above their heads. Motorized shoulder flexion also allowed these patients to have a deeper work space, as demonstrated by patient S2 performing reaching motions over a table Figure 6. Humeral rotation and shoulder abduction widened the work space for all patients and facilitated reaching to the midline for bimanual tasks.

The powered wrist served mostly to preposition a functional wrist angle and facilitate better hand operation. The increased number of powered joints also allowed more precise orientation of the hand in space. For example, a ring could be moved across a geometric wire Figure 6 B.

Many different hand grasps were possible with the DEKA arm system; patients were able to attempt 3-jaw chuck, lateral pinch, fine pinch, power grasp, and tool grip. Patients varied in their abilities to control different grasps: one patient could reliably control 4 hand-grasp patterns, another could control up to 3, and the third could reliably control 2.

Training with a smaller number of hand grasps improved performance. Choosing different hand-grasp patterns was also more difficult than operating the wrist or elbow motions, consistent with the virtual data presented above. The different grasps facilitated different functional activities. For example, the power grip allowed a firm grasp of a hammer, and the fine pinch enabled picking up small objects Figure 6 A.

This study presents experiments on real-time control of highly articulated artificial arms in patients with targeted muscle reinnervation—a novel neural-machine interface.

In this study, we demonstrated that a pattern-recognition algorithm can be used to decode surface EMG data from reinnervated muscles and provide intuitive control of powered elbows, wrists, and hands.



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